Trikafta for Patients With Non-cystic Fibrosis Bronchiectasis

Inclusion Criteria: * Provision of signed and dated informed consent form * Stated willingness to comply with all study procedures and availability for the duration of the study * Radiologic and other clinical evidence leading to a diagnosis of NCFBE * 1 CF-causing mutation and/or sweat chloride measurement ≥ 30 mEq/L and \< 60 mEq/L * Able to perform spirometry meeting American Thoracic Society (ATS) criteria for acceptability and repeatability, and FEV1 40-90% predicted * Clinically stable in the past 4 weeks with no evidence of bronchiectasis exacerbation * Willingness to use at least one form of acceptable birth control including abstinence or condom with spermicide. This will include birth control for at least one month prior to screening and agreement to use such a method during study participation for an additional four weeks after the last administration of Study Drug (for postmenopausal or other women who are without the possibility of becoming pregnant, this requirement may be waived) * Ability to take Trikafta * Agreement to adhere to all current medical therapies as designated by the study physician Exclusion Criteria: * Diagnosis of cystic fibrosis * Documented history of drug or alcohol abuse within the last year * Pulmonary exacerbation or changes in therapy for pulmonary disease in the 4 weeks prior to screening * Listed for lung or liver transplant at the time of screening * Cirrhosis or elevated liver transaminases \> 3 times the upper limit of normal (UL…