Optimal Exercise Frequency to Reduce Liver Fat in Centrally Obese Adults With Non-Alcoholic Fatty… (NCT05741957) | Clinical Trial Compass
Active — Not RecruitingNot Applicable
Optimal Exercise Frequency to Reduce Liver Fat in Centrally Obese Adults With Non-Alcoholic Fatty Liver Disease
Hong Kong300 participantsStarted 2023-03-02
Plain-language summary
This study aims to examine the comparative effectiveness of different exercise frequencies (once-a-week vs. thrice-a-week) for reducing liver fat in centrally obese adults with non-alcoholic fatty liver disease (NAFLD), with weekly exercise volumes aligned with the World Health Organization's physical activity recommendations.
Who can participate
Age range18 Years – 69 Years
SexALL
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Inclusion criteria
✓. Cantonese, Mandarin, or English speaking Chinese;
✓. Aged 18-69;
✓. Male or female;
✓. Centrally obese according to the Asian-specific cut-off (waist circumference ≥90 cm for males; ≥80 cm for females) and with BMI ≥23;
✓. With NAFLD (defined as \>5% intrahepatic triglycerides assessed by 1H-MRS);
✓. Willing to participate in exercise training to improve NAFLD.
Exclusion criteria
✕. Regular exercise training (\>3 sessions of \>60 min of moderate-intensity exercise training weekly) in the past 6 months;
✕. Medical history of cardiovascular disease, chronic pulmonary or kidney disease, heart failure, cancer, and/or liver disease except NAFLD;
✕. Somatic conditions that limit exercise participation (e.g., limb loss);
✕. Impaired mobility due to chronic disease (e.g., chronic arthritis/osteoarthritis, neurological, musculoskeletal, and autoimmune diseases);
✕. Daily smoking habit;
✕. Excess alcohol consumption (daily ≥20 g of alcohol for men and ≥10 g for women) in the past 1 year;
✕. Consumption of certain drugs (e.g., tamoxifen and estrogen) known to be secondary causes of steatosis;
What they're measuring
1
Change in Liver Fat
Timeframe: Baseline and 4 months (post-intervention)
✕. Surgery, therapy, or medication for obesity or weight loss in the past 6 months (e.g., gastric bypass, gastric band, sleeve gastrectomy, gastric reduction duodenal switch, or dietitian-prescribed dietary program);