Clincal Study of Reduced Target Radiotherapy in Nasopharyngeal Carcinoma (NCT05741008) | Clinical Trial Compass
CompletedNot Applicable
Clincal Study of Reduced Target Radiotherapy in Nasopharyngeal Carcinoma
China20 participantsStarted 2023-01-01
Plain-language summary
To determine whether subtractive radiotherapy can significantly reduce the acute side effects of radiotherapy and improve the quality of life of patients on the basis of ensuring the existing curative effect.
Who can participate
Age range18 Years – 65 Years
SexALL
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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion criteria
✓. Histopathologically confirmed nasopharyngeal nonkeratologic carcinoma (differentiated or undifferentiated, i.e., WHO type II or Type III).
✓. The clinical stage is TanyN2-3M0, III-IVa (AJCC 8th edition stage).
✓. Patients who have not received radiation therapy before.
✓. After induction chemotherapy, CR or PR were evaluated by radiography.
✓. Age 18-65 years old.
✓. ECOG score of 0-1.
✓. Good organ function
✓. The patient has signed an informed letter and is willing and able to comply with the planned visits, treatment plans, laboratory tests and other research programs.
Exclusion criteria
✕. Patients with keratinizing squamous cell carcinoma account for only about 5% of the total pathological types, and the sensitivity of radiotherapy is poor compared with the other two types heterogeneous, so nasopharyngeal carcinoma with pathology of keratinizing squamous cells (WHO type I) is excluded.
✕. Patients with relapsed and distant metastases.
✕. The metastatic lymph nodes are located in the target area (Ib zone, the lateral group of the retropharyngeal lymphatic drainage area (VII), and the cervical lymphatic rainage area The medial border moves from top to bottom from the medial border of the common carotid artery to the lateral border, from the annular cartilage to the superior sternal border, sternoclavicular.The triangular area between the anterior and posterior edges of the medial mastoid muscle and the anterior and lateral border of the jugular arteriovenous sheath and lateral border of the thyroid glanddomain).
What they're measuring
1
incidence of acute mucosal ulcers with a toxicity grade 3 or above
Timeframe: up to 6 months
Trial details
NCT IDNCT05741008
SponsorFirst Affiliated Hospital of Kunming Medical University