Clinical Effects of Limosilactobacillus Reuteri Probiotics as an Adjunct to the Treatment of Periodontitis

Inclusion Criteria: * Patients over 18 years old, who intend to voluntarily participate in the study and: * Have a definitive diagnosis of stage II, grade A, B or C, generalized periodontitis (2018, World Workshop); * Have at least 3 natural teeth maintained per quadrant. Exclusion Criteria: * • Patients unable to understand the instructions necessary to participate in the study or unable to give informed consent; * Patients who have received any type of periodontal treatment 2 months prior to the start of study participation; * Pregnant or breastfeeding patients; * Patients with associated systemic pathology, such as diabetes, HIV, asthma, hyperthyroidism, immune system pathologies, lichen erosive or other pathologies treated with corticosteroids or immunosuppressants; * Patients undergoing therapy with drugs that may interfere with the response of the gingival tissues: anti-inflammatory drugs, anticonvulsants (phenytoin and sodium valproate), immunosuppressants (cyclosporin-A and tacrolimus) and antihypertensives (nifedipine and verapamil hydrochloride); * Patients undergoing anticoagulant therapy; * Patients allergic to both lidocaine, articaine and mepivacaine; * Patients who require antibiotic prophylaxis for bacterial endocarditis; * Patients who have had antibiotic therapy within 2 months of study participation; * Patients using chlorhexidine, or other mouthwashes or elixirs; * Patients undergoing orthodontic treatment.