CompletedPhase 1

UVB-Induced MVP Release in Human Skin

United States8 participantsStarted 2018-07-16

Plain-language summary

This study is designed to assess if ultraviolet B radiation (UVB) found in sunlight causes the release of microvesicle particles in human skin, and if antioxidant vitamins can block their production.

Who can participate

Age range

21 Years – 45 Years

Sex

MALE

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Male subjects * Ages 21 to 45 * Skin type: Fitzpatrick Type I or II Exclusion Criteria: * Have underlying diseases that could affect wound healing * On medications that are known photosensitizers (e.g., doxycycline) or anti-inflammatories (e.g., NSAIDS \[except for low-dose aspirin\] or steroids) * History of abnormal scarring (e.g., keloids) * Should not be on Vitamin C or E supplements for past month * Unable to understand/complete informed consent * Large volar arm tattoos that would inhibit the ability to conduct/evaluate the skin testing * Renal compromise/kidney stones or allergy to Vitamin C/Vitamin E or lidocaine anaesthetic * Use of tanning bends or recent UVB exposure to the areas in the past 3 months * Recent (within 1 week) use to sunscreen to volar forearms

Questions worth asking your doctor

Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.

1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?

Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.

Questions for the trial coordinator

The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.

1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?

A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.

What they're measuring

Change in microvesicle particles (MVP) levels from baseline

Timeframe: Day 8

Trial details

NCT IDNCT05734235

SponsorWright State University

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2020-03-05

View on ClinicalTrials.gov More Ultraviolet B Radiation trials