The goal of this observational and interventional study is to better understand the involvement of the cerebellum in the brain reward system in persons with alcohol use disorder (AUD). The main questions it aims to answer are: 1. What is the nature of cerebellar input to the ventral tegmental area (VTA) in the brain reward system, and how is it perturbed in AUD? 2. What is the relationship between measures of cerebellar integrity and magnitude of reward activation to alcohol-related cues in cerebellar, VTA and other brain reward structures? 3. What is the therapeutic potential of cerebellar transcranial direct current stimulation (tDCS) for modulating alcohol cue reactivity, associated alcohol craving, and cerebellar - VTA functional connectivity in the brain reward system? Persons with AUD will be compared with healthy control participants.
Age range
25 Years – 55 Years
Sex
ALL
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Craving for alcohol during the cue reactivity task as assessed by a rating scale
Timeframe: 28 minutes
Resting state functional connectivity during tDCS
Timeframe: 28 minutes
Brain activation to alcohol cues
Timeframe: 28 minutes
Brain functional connectivity to alcohol vs non-alcohol cues
Timeframe: 28 minutes
Brain activation related to reward prediction during the monetary incentive task
Timeframe: 18 minutes
Brain functional connectivity related to reward prediction during the monetary incentive task
Timeframe: 18 minutes
Brain activation to reward prediction error during the monetary incentive task
Timeframe: 18 minutes
brain functional connectivity to reward prediction error during the monetary incentive task
Timeframe: 18 minutes
Percentage of trials with a conditioned response during the classical eyeblink conditional task
Timeframe: 21 minutes
Mean time (in milliseconds) at which peak of conditioned response occurs during the classical eyeblink conditional task
Timeframe: 21 minutes