The Effect of Pituitrin on the Patients With Pulmonary Hypertension Undergoing Cardiac Surgery

Inclusion Criteria: * age ≥18 years and ≤80 years; * scheduled for elective cardiopulmonary bypass heart surgery (adult congenital heart disease surgery, coronary artery bypass grafting, valve replacement, valvuloplasty, heart transplantation and aortic surgery); * Patients who had pulmonary hypertension (Mean pulmonary artery pressure at rest ≥ 25mmhg or pulmonary artery systolic pressure (PASP) ≥ 40mmhg as shown by echocardiography); * sign informed consent. Exclusion Criteria: * use pituitrin or vasopressin before operation; * Patients who had acute coronary syndrome; * preoperative use of left ventricular assist devices other than intra aortic balloon - pump (IABP); * Patients who had liver, thyroid and adrenal diseases, severe lung diseases, diabetes; * Patients who had preoperative renal insufficiency (The increase of serum creatinine (SCR) within 48 h ≥ 0.3mg/dl (or ≥ 26.5 μ mol/L)； Or it is known or speculated that the increase of SCR in the past 7 days is more than 1.5 times of the basic value; Or 0.5ml/kg urine volume per hour for 6H); * Patients who had severe carotid artery stenosis, preoperative stroke, mental disorder and other difficult to communicate and cooperate; * Patients who had peripheral vascular disease, allergy to vasopressin or pituitrin, severe hyponatremia (na+ \< 130 mmol/l), acute mesenteric ischemia, pregnancy, malignant tumors, required ECMO and underwent emergency surgery or reoperation; * Patients who had participated in other clinical stu…