TerminatedNot Applicable

PROtecting Maternal Brains From Injury and Stroke

Stopped: Lack of funding

United States26 participantsStarted 2023-05-04

Plain-language summary

The purpose of this study is to test a new approach to blood pressure management in postpartum preeclampsia. There will be two groups of patients in this early stage single center trial. Both groups of study participants (observational and interventional) will be treated with standard blood pressure medications while undergoing continuous non-invasive blood pressure and near infrared spectroscopy (NIRS) monitoring for 24 hours. The interventional group will have personalized blood pressure targets according to results of NIRS monitoring which will be updated in real time.

Who can participate

Age range18 Years – 55 Years

SexFEMALE

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Inclusion criteria

✓. measured systolic BP ≥160 mmHg and/or diastolic BP ≥110 mmHg on two or more occasions, 15 minutes apart OR
✓. severe headache refractory to standard over-the-counter medications (acetaminophen, ibuprofen)

What they're measuring

Percentage of Time Mean Arterial Pressure (MAP) is Outside the Target Range

Timeframe: 24 hours

Trial details

NCT IDNCT05726279

SponsorColumbia University

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2025-02-28

Results submitted2026-02-25

View on ClinicalTrials.gov More Preeclampsia trials