Trained and Heterologous Induced-immune Responses to Tropical Infectious Diseases

Inclusion Criteria: * Healthy children aged 1 to 12 years * Residence in the study area or surroundings for the period of the study * Written informed consent from parents/legally acceptable representatives and an assent for children (age will depend on local country regulations) Exclusion Criteria: * Complicated symptomatic malaria (defined according to standard World Health Organization criteria) * Anaemia (Hb\<7g/dL), * Any (chronic) illness that requires immediate clinical care * Family history of sudden death or of congenital or clinical conditions known to prolong QTcB or QTcF interval or e.g. family history of symptomatic cardiac arrhythmias, with clinically relevant bradycardia or severe cardiac disease * Any treatment which can induce a lengthening of Q.T. interval * Known history of hypersensitivity or allergic reactions to piperaquine or other aminoquinolines and Lumefantrine * Receipt of any blood transfusion or immunoglobulins within 3 months * Known history of hypersensitivity or allergic reactions to artesunate * Severe malnutrition (weight-for-height being below -3 standard deviation or less than 70% of median of the NCHS/WHO normalized reference values). * Weight below 5 kg * Current participation in malaria vaccine trials * Current active participation in any trial involving administration of investigational drug. * Any severe drug-drug interactions, antimalarial, antihelminth and antibiotics