Selecting Specific Bio-markers and Researching Mechanisms of Immune Regulation From Inhalation In… (NCT05718830) | Clinical Trial Compass
CompletedNot Applicable
Selecting Specific Bio-markers and Researching Mechanisms of Immune Regulation From Inhalation Injury and Traumatic Lung Injury Based on Single Cell Sequencing Technology
China21 participantsStarted 2021-01-01
Plain-language summary
The goal of this observational study is to profile the circulating immunological traits of patients with traumatic lung injury (TLI) and inhalation injury (ILI),providing a new direction for the depth research of the pathogenesis, and providing new immune-related targets for diagnosis of the severity of lung injury and treatment.
The investigators performed scRNA-seq of neutrophil and peripheral blood mononuclear cells (PBMCs) from 10 ml fresh circulating blood from 3 patients with TLI and 3 patients with ILI at longitudinal timepoints,as well as peripheral blood from 3 health controls(HCs).
Who can participate
Age range18 Years – 90 Years
SexALL
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Inclusion criteria
✓. Lung injury caused by burn trauma is confirmed, and the patient is hospitalized within 24 hours after burn or trauma (the clinician can make a definite diagnosis of lung injury based on the comprehensive judgment of the patient's etiology, history, clinical manifestations, blood gas analysis, laboratory tests and imaging);
✓. Patients with inhalation injury caused by head, face and neck burns or inhalation injury combined with multiple body burns \< 30%;
✓. Patients with simple inhalation injury;
✓. The normal control group should have no smoking history and be normal population;
✓. According to the provisions of Good Clinical Practice(GCP), the informed consent has been obtained and the informed consent has been signed to volunteer for the test.
Exclusion criteria
✕. Basic pulmonary diseases like chronic obstructive pulmonary disease (COPD), asthma and et al;
✕. Severe organ dysfunction;
✕. Autoimmune diseases;
What they're measuring
1
Computerized tomography, CT
Timeframe: 1day
2
Computerized tomography, CT
Timeframe: 3 day
3
Computerized tomography, CT
Timeframe: through study completion, an average of 2 weeks
4
Partial pressure of carbon dioxide in arterial blood, PaCO2
Timeframe: 1day
5
Partial pressure of carbon dioxide in arterial blood, PaCO2
Timeframe: 3 day
6
Partial pressure of carbon dioxide in arterial blood, PaCO2
Timeframe: through study completion, an average of 2 weeks
7
Oxygenation index and Fraction of Inspired Oxygen will be combined to report FiO2/PaO2
Timeframe: 1 day
8
Oxygenation index and Fraction of Inspired Oxygen will be combined to report FiO2/PaO2