CompletedNot Applicable

Selecting Specific Bio-markers and Researching Mechanisms of Immune Regulation From Inhalation Injury and Traumatic Lung Injury Based on Single Cell Sequencing Technology

China21 participantsStarted 2021-01-01

Plain-language summary

The goal of this observational study is to profile the circulating immunological traits of patients with traumatic lung injury (TLI) and inhalation injury (ILI),providing a new direction for the depth research of the pathogenesis, and providing new immune-related targets for diagnosis of the severity of lung injury and treatment. The investigators performed scRNA-seq of neutrophil and peripheral blood mononuclear cells (PBMCs) from 10 ml fresh circulating blood from 3 patients with TLI and 3 patients with ILI at longitudinal timepoints,as well as peripheral blood from 3 health controls(HCs).

Who can participate

Age range

18 Years – 90 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion criteria

. Lung injury caused by burn trauma is confirmed, and the patient is hospitalized within 24 hours after burn or trauma (the clinician can make a definite diagnosis of lung injury based on the comprehensive judgment of the patient's etiology, history, clinical manifestations, blood gas analysis, laboratory tests and imaging);
. Patients with inhalation injury caused by head, face and neck burns or inhalation injury combined with multiple body burns \< 30%;
. Patients with simple inhalation injury;
. The normal control group should have no smoking history and be normal population;
. According to the provisions of Good Clinical Practice(GCP), the informed consent has been obtained and the informed consent has been signed to volunteer for the test.

Exclusion criteria

Questions worth asking your doctor

Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.

1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?

Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.

Questions for the trial coordinator

The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.

1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?

A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.

What they're measuring

Computerized tomography, CT

Timeframe: 1day

Computerized tomography, CT

Timeframe: 3 day

Computerized tomography, CT

Timeframe: through study completion, an average of 2 weeks

Partial pressure of carbon dioxide in arterial blood, PaCO2

Timeframe: 1day

Partial pressure of carbon dioxide in arterial blood, PaCO2

Timeframe: 3 day

Partial pressure of carbon dioxide in arterial blood, PaCO2

Timeframe: through study completion, an average of 2 weeks

Oxygenation index and Fraction of Inspired Oxygen will be combined to report FiO2/PaO2

Timeframe: 1 day

Trial details

NCT IDNCT05718830

SponsorChanghai Hospital

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2021-12-31

View on ClinicalTrials.gov More Traumatic Lung Injury trials

Plain-language summary

Who can participate

Age range

18 Years – 90 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion criteria

. Lung injury caused by burn trauma is confirmed, and the patient is hospitalized within 24 hours after burn or trauma (the clinician can make a definite diagnosis of lung injury based on the comprehensive judgment of the patient's etiology, history, clinical manifestations, blood gas analysis, laboratory tests and imaging);
. Patients with inhalation injury caused by head, face and neck burns or inhalation injury combined with multiple body burns \< 30%;
. Patients with simple inhalation injury;
. The normal control group should have no smoking history and be normal population;
. According to the provisions of Good Clinical Practice(GCP), the informed consent has been obtained and the informed consent has been signed to volunteer for the test.

Exclusion criteria

What they're measuring

Computerized tomography, CT

Timeframe: 1day

Computerized tomography, CT

Timeframe: 3 day

Computerized tomography, CT

Timeframe: through study completion, an average of 2 weeks

Partial pressure of carbon dioxide in arterial blood, PaCO2

Timeframe: 1day

Partial pressure of carbon dioxide in arterial blood, PaCO2

Timeframe: 3 day

Partial pressure of carbon dioxide in arterial blood, PaCO2

Timeframe: through study completion, an average of 2 weeks

Oxygenation index and Fraction of Inspired Oxygen will be combined to report FiO2/PaO2

Timeframe: 1 day