BENTO - Bronchoscopic Lung Volume Reduction in Severe Emphysema Using Thermoablation

Inclusion Criteria: * Age: ≥ 40 years and ≤ 75 years * Written informed consent obtained from the patient * Severe emphysema with indication for BTVA: * bilateral heterogeneous emphysema of the upper lobes in GOLD stage 3/4 and * evidence of severe emphysema in high-resolution computed tomography (not older than 6 months prior to inclusion) and * functional evidence of severe pulmonary hyperinflation and * FEV1 post lysis between 20% and \< 45% (calculated) and * Total lung capacity (TLC) ≥ 100% (calculated) and * Residual volume (RV) \> 175% (calculated) and * arterial blood gas values of: PaCO2 ≤ 50 mmHg; PaO2 \> 50 mmHg on room air and * marked dyspnoea with a score ≥ 2 on the Medical Research Council modified scale (mMRC) and * 6-minute walk test \> 140 metres * Patient-specific, pre-interventional exhaustion of conservative treatment options * optimised medical therapy (according to the GOLD guidelines) and * Non-smoker for 6 months prior to inclusion * Evidence of completed pulmonary and geriatric rehabilitation in the last 4 years * ≥ 6 weeks outpatient or * ≥ 3 weeks inpatient or * Individual Participation in regular physical activities that go beyond the activities of daily living (e.g. a walking programme) * According to the investigator's assessment mentally and physically able to participate in the study procedures and visits * Indication within the framework of an interdisciplinary case conference with specialists in pneumology, radiology and thoracic surgery in…