The Efficacy of Systemic Valacyclovir (Valtrex) on Periodontitis

Inclusion Criteria: * Patients must be systemically healthy, Class I dental category. * Involved teeth must have periodontal disease detectible by periodontal examination. * Subjects with deep vertical periodontal lesions (\>6 mm) showing no radiographic crestal alveolar lamina dura Exclusion Criteria: * Presence of any disease or medication that alters the immune system or interferes with healing ability Smokers (more than 10 cigarettes per day) * External or internal tooth resorption * Tooth perforation from the pulp cavity through the tip of the root exposing the tissue to material in the oral cavity. * Pregnant or nursing mothers because hormonal factors may influence the condition. * Allergies or adverse reactions to valacyclovir. * Patients under the age of 18. * Patients with renal impairment or reduced renal function. * Patients requiring hemodialysis or peritoneal dialysis.