Computerized Cognitive Training to Protect Cognitive Function Among Hypertension Patients (NCT05704270) | Clinical Trial Compass
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Computerized Cognitive Training to Protect Cognitive Function Among Hypertension Patients
China200 participantsStarted 2023-02-01
Plain-language summary
Hypertension is an risk factor for cognitive impairment. The primary objective of this study is to evaluate the efficacy of 12-week computerized cognitive training in people with hypertension and mild cognitive impairment. The researchers will further investigate the long-term effects of cognitive training by prolonging the intervention for 24 weeks among a randomly selected sub-group.
Who can participate
Age range60 Years
SexALL
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Inclusion criteria
✓. Older than 60 years;
✓. Completed 6 or more years of education;
✓. Untreated or under treatment hypertension;
✓. Complaint of memory decline within 1 year;
✓. Global cognitive score measured by the Montreal Cognitive Assessment is below 26;
✓. Agree to receive cognitive function evaluation, randomization, and follow-up investigation as required;
Exclusion criteria
✕. Unable to complete cognitive function evaluation due to vision, hearing, and other problems;
✕. Have been diagnosed of dementia or MMSE score ≤ 20;
✕. Unable to use the cognitive training equipment after 2 times instructions;
✕. Alcohol abuse or taking drugs that could affect cognitive function (antihistamines, antipsychotics);
✕. Diabetes patients;
✕. Moderate to severe decrease in glomerular filtration rate (eGFR\<30 ml/min /1.73m2);
✕. Systolic blood pressure ≥180 mmHg or/and diastolic blood pressure ≥110 mmHg; or orthostatic hypotension (defined as the third standing SBP\<100mmHg);
What they're measuring
1
Global cognitive function change measured by BCAT in 12 weeks