Perfusion MRI-targeted Joint Embolization for Chronic Musculoskeletal Pain of the Shoulder, Hip a… (NCT05700682) | Clinical Trial Compass
RecruitingNot Applicable
Perfusion MRI-targeted Joint Embolization for Chronic Musculoskeletal Pain of the Shoulder, Hip and Knee
United States120 participantsStarted 2023-07-15
Plain-language summary
In this work the investigators will study the relationship between chronic musculoskeletal pain and abnormal blood flow (neovascularity) around the shoulder, hip and knee. Veterans with as history of chronic shoulder, hip or knee pain and mild/moderate joint degenerative changes will be potential study subjects. Blood flow around joints will be evaluated using perfusion magnetic resonance imaging (MRI). Participants with demonstrably abnormal blood flow around their painful joint will be eligible for enrollment in a pilot study of joint embolization to treat their pain. Participants who choose to not undergo treatment will be re-assessed with MRI after one year to characterize the natural history of joint neovascularity and its relationship to pain.
Who can participate
Age range25 Years – 80 Years
SexALL
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Inclusion criteria
✓. Participants must be Veterans who receive care in the VA system.
✓. Participants must have a history of chronic pain of the shoulder, hip or knee for at least 1 year.
✓. Participants must have mild to moderate degenerative changes of the painful joint as depicted on prior imaging (X-ray, CT or MRI).
✓. Participants must have undergone at least one failed primary treatment for their chronic pain (e.g. physical therapy, NSAIDs, steroid injection).
✓. Participants must have an MRI of their painful joint (shoulder, hip or knee) ordered by a clinical provider.
✓. Participants must have enrolled in the Diagnostic Arm of the study and must have undergone perfusion MR imaging of their painful joint.
✓. Participants must have evidence of peri-articular hypervascularity on their perfusion MR exams. This will be determined by the study PIs.
Exclusion criteria
✕. Acute injury in the last 12 weeks.
What they're measuring
1
Primary Clinical Outcome (Hip and Knee, Therapeutic Arm Only)
Timeframe: Score obtained at follow-up visit 6 months after intervention
2
Primary Clinical Outcome (Shoulder, Therapeutic Arm Only)
Timeframe: Score obtained at follow-up visit 6 months after intervention
3
Primary Imaging Outcome (Therapeutic Arm Only)
Timeframe: Research MRI obtained 3 months after intervention