Oral Glibenclamide in Preterm Infants With Hyperglycaemia (GALOP)

Inclusion Criteria: * Newborn less than 34 week of amenorrhea corrected age * Birth weight \< 1500 g * Birth term \< 32 week of amenorrhea * Hyperglycemia ≥ 10 mmol/l in 2 measurements, 3 hours apart after potential reduction of glucose intakes following each department's protocol * Secure venous access point (umbilical venous catheter or epicutaneo-cava catheter) * Enteral feeding considered before inclusion or already established * Consent obtained from persons holding parental authority * Beneficiary of social security Exclusion Criteria * Contraindication to enteral feeding (at the discretion of the clinician responsible for the child) * Contraindication to glibenclamide according to current SPC * Foetal growth restriction (FGR) birth weight \< 3rd percentile (AUDIPOG definition) * Severe birth defect, including cardiac malformation associated with a risk of myocardial ischemia * Severe sepsis requiring mechanical ventilation or haemodynamic support * Severe renal dysfunction (serum creatinine \> 120 µmol/l) * Severe hepatocellular failure (V factor less than the standard laboratory range for the age) and/or severe cholestasis (\> 50 µmol/L) * Hyperglycemia associated with an error in administering glucose infusion * Profound hypophosphoremia (\< 1 mmol/l) * Hypersensitivity to glibenclamide or other sulphonylureas or sulphonamides, or one of the excipients * Patient with continuous insulin IV administration * Patient treated with miconazole