This is a community-based study requiring participant-self-enrollment, that can help to increase the rates of genetic testing among the family members of people who have been diagnosed with a hereditary cancer syndrome. The two main factors in this study are the IGNITE-TX intervention (website and navigator) and the free genetic counseling and testing.
The IGNITE-TX Intervention is an innovative multi-modal intervention, with two components: a) interactive web "IGNITE-TX Hub" and b) genetic family navigators.
Who can participate
Age range18 Years
SexALL
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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion criteria
ā. 18 years of age or older
ā. Speaks and/or reads English or Spanish
ā. Has known deleterious/pathogenic mutation or suspected deleterious/pathogenic variant in BRCA1 or BRCA2 (HBOC) or MLH1, MSH2, MSH6, PMS2, or EPCAM (LS)
ā. Has access to the internet or phone and can send and receive email and/or text messages at a US telephone number
ā. Has at least one at-risk relative who meets inclusion criteria for first-degree relative
Exclusion criteria
ā. Has no at-risk relatives meeting inclusion criteria
ā. Has negative germline genetic testing or only variant of uncertain significance
ā. Unwilling or unable to provide consent 4.2. AT-RISK RELATIVES (ARR)
ā. 18 years of age or older
ā. Speaks and reads English or Spanish
What they're measuring
1
Measure enrollment of probands and at-risk relatives over a 6-month period
Timeframe: Up to 6 months
2
Measure response rate to baseline and follow-up surveys by probands and at-risk relatives
ā. Can provide proof of deleterious/suspected deleterious HBOC or LS variant present in a first degree relative (biological mother or father, biological child, or full sibling)
ā. Has access to internet or phone and can send and receive email and/or text messages at a US telephone number