This study will evaluate a new form of non-invasive deep brain therapy for individuals with generalized chronic pain. Low-intensity transcranial focused ultrasound stimulation will first be delivered using a range of stimulation parameters during psychophysical and physiological monitoring. A well-tolerated stimulation protocol will be selected for subsequent testing in a blinded randomized sham-controlled cross-over trial. The trial will evaluate brain target engagement using magnetic resonance imaging and CVAS and PROMIS numerical rating scales of pain.
Age range
18 Years – 65 Years
Sex
ALL
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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
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Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
Target engagement: brain activation
Timeframe: 1 day At MRI study visit
Target engagement: brain connectivity
Timeframe: 1 day At MRI study visit
Pain intensity: momentary change
Timeframe: 1 day At stimulation visit
Pain intensity: subjective state
Timeframe: 1 day At stimulation visit
Depression scale: subjective state
Timeframe: 1 day At stimulation visit
Anxiety scale: subjective state
Timeframe: 1 day At stimulation visit