Cow's milk contains two types of β-casein: A1 and A2. It is evident from human clinical trials that milk with A1 protein produces more hydrogen and symptoms of lactose intolerance. A pro-inflammatory μ-opioid peptide BCM-7 is released from A1 but not from A2. Milk containing A1 β-casein produced more inflammatory markers than A2 β-casein. This is a double-blinded, randomized, controlled trial conducted to determine if there are changes in inflammatory markers following two weeks of milk feeding, due to milk containing A1 and A2 beta-casein as compared to milk containing only A2 beta-casein.
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Difference in inflammation between commercial and A2 milk
Timeframe: Baseline blood draw on day 1 and within the 3 hours following milk dose on day 15
Difference in hydrogen between commercial and A2 milk
Timeframe: Within the 6 hours following milk dose on day 15
Difference in symptoms between commercial and A2 milk
Timeframe: From day 1 to day 14 after 500 ml milk consumption and within the 6 hours following milk dose on day 15