NIMH K23: Modulation of Frontoparietal Dynamics in Adolescent Working Memory Deficits (NCT05662280) | Clinical Trial Compass
RecruitingNot Applicable
NIMH K23: Modulation of Frontoparietal Dynamics in Adolescent Working Memory Deficits
United States40 participantsStarted 2022-12-01
Plain-language summary
Working memory (WM) deficits are a transdiagnostic feature of adolescent psychopathology that substantially contribute to poor clinical and functional outcomes. This proposal will utilize a multimodal neuroscientific approach to investigate whether non-invasive brain stimulation can modulate the neural mechanisms underlying adolescent WM deficits. Directly in line with NIMH priorities, the researchers will identify the contributing roles of prefrontal and parietal regions in WM processes, as well as identify optimal targets and parameters for novel brain-based treatments in adolescent psychopathology. This study is funded by the NIMH-K23
Who can participate
Age range12 Years – 18 Years
SexALL
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Inclusion criteria
✓. Ability to provide assent and have parent provide parental permission
✓. English fluency of the participant and the legal guardian/parent
✓. 12-18 years
✓. Parent rating on BRIEF-2 Working Memory: Greater than 1.0 SD above normative mean.
✓. IQ \> 80
✓. Clinical diagnosis of attention deficit hyperactivity disorder (ADHD): predominantly inattentive type, predominantly hyperactive/impulsive type, combined type, or unspecified type. Diagnostic criteria will be confirmed with NICHQ Vanderbilt Assessment Scales-Parent.
Exclusion criteria
✕. Intracranial pathology from a known genetic disorder (e.g., NF1, tuberous sclerosis) or from acquired neurologic disease (e.g. stroke, tumor), cerebral palsy, history of severe head injury, or significant dysmorphology
✕. History of fainting spells of unknown or undetermined etiology that might constitute seizures
✕
What they're measuring
1
Change in Theta-Gamma Coupling After Sham iTBS
Timeframe: Theta-gamma coupling will be obtained immediately before (i.e., pre-iTBS) and after iTBS (i.e., post-iTBS). There will be approximately 5 minutes between the pre and post EEG recordings. The change between pre-iTBS and post-iTBS is the outcome variable.
2
Change in Theta-Gamma Coupling after Active iTBS
Timeframe: Theta-gamma coupling will be obtained immediately before (i.e., pre-iTBS) and after iTBS (i.e., post-iTBS). There will be approximately 5 minutes between the pre and post EEG recordings. The change between pre-iTBS and post-iTBS is the outcome variable.
. History of seizures, diagnosis of epilepsy, or immediate (1st degree relative) family history epilepsy
✕. Any progressive (e.g., neurodegenerative) neurological disorder
✕. Chronic (particularly) uncontrolled medical conditions that may cause a medical emergency in case of a provoked seizure (cardiac malformation, cardiac dysrhythmia, asthma, etc.)
✕. Contraindicated metal implants in the head, brain or spinal cord (excluding dental implants, braces or fillings)