Anti-Schistosomiasis Sm14-vaccine in Senegal

Inclusion Criteria: * Man living in villages in the Saint Louis region where schistosomiasis is endemic. * Having an infectious history of schistosomiasis. * Adult between 18 and 49 years old at the time of the first injection. * Have received pre-treatment with PZQ four to eight weeks before inclusion. * Consent signed by the volunteer after information. * Satisfactory state of health, confirmed on clinical examination and following biological assessment (Vpi / W-1). * Available for the duration of the trial. * To be negative to the Covid-19 antigenic test Exclusion Criteria (Non inclusion criteria) : * Subject not meeting one of the inclusion criteria. * Participation to a previous anti-schistosomiasis vaccine clinical trial. * Participation in another ongoing clinical research * Current or previous chronic administration (defined as more than 14 days) of immunosuppressive drugs or other immune modulating drugs. * Known hypersensitivity to any component present in the Sm14 vaccine, or to any given vaccine, and / or history of allergic disease. * Acute illness at the time of inclusion. * Other conditions which, according to the PI, can potentially represent a danger to the subject to be included.