Body Weight Adjusted Clopidogrel Treatment in Patients With CORonary Artery Disease

Inclusion Criteria: * Patients, male or female, ≥18 years of age * Patients treated for CCS with clopidogrel 75mg QD (aspirin 100mg QD). * Patients must be treated with clopidogrel 75mg for at least one month * Patients must give consent by means of a signed informed consent Exclusion Criteria: * Contra-indication for aspirin * Contra-indication for clopidogrel or prasugrel * Occurrence of an ischemic event after PCI or ACS (stroke, myocardial infarction, or coronary revascularization) * Presence of unstable angina complaints. * Presence of two CYP2C19 Loss-of-function (LOF) alleles (\*2 or \*3) * Scheduled for cardiac valve surgery * Indication for chronic oral anticoagulants * Expected life span of less than one year * Pregnancy * Suboptimal stent placement as determined by the cardiologist. * Patients at increased risk of bleeding with two of the following characteristics: liver cirrhosis with portal hypertension, enhanced bleeding tendency, active malignancy in the past 12 months, thrombocytopenia, major surgery in the past month, spontaneous intracerebral haemorrhage, traumatic intracerebral haemorrhage in the past 12 months, major bleeding requiring hospitalisation or blood transfusion in the past month, ischaemic CVA in the past 5 months. * Known with established stent thrombosis