Efficacy and Safety of Shen Que (RN8) Moxibustion in Unexpected POR

Inclusion Criteria: * ≥35 years old with normal pre-stimulation ovarian reserve parameters (antral follicle count (AFC) ≥ 5 or anti-mullerian hormone (AMH) ≥1.2 ng/ml) and with an expected poor ovarian response (fewer than 4 oocytes) after standard ovarian stimulation. Exclusion Criteria: * Individuals with a Body Mass Index (BMI) ≥ 35 Kg/m2 * Those using the natural cycle or mild stimulation for IVF/intracytoplasmic sperm injection (ICSI) treatment * Those with a history of unilateral oophorectomy or recurrent pregnancy loss, defined as two or more spontaneous abortions * Acceptors of donated oocytes or performed either In vitro Maturation (IVM) or blastocyst biopsy for Preimplantation Genetic Diagnosis (PGD) or Preimplantation Genetic Testing for Aneuploidies (PGT-A) * Those previously diagnosed with congenital (e.g., mediastinal uterus and double uterus) or acquired (e.g., submucosal myoma and adenomyosis) uterine abnormalities * Patients with extremely advanced age ( ≥ 45 years old) * Presence of a non-surgically treated hydrosalpinx or endometrial polyp and an ovarian endometriosis cyst requiring surgery, during ovarian stimulation