CompletedNot Applicable

Changes in Tactile Perception in People With Segmental Exclusion Syndrome

France34 participantsStarted 2022-09-26

Plain-language summary

Segmental exclusion syndrome is characterised by the non-use or under-use of a limb segment, most oftenly reported in the distal part, following an injury, without affecting the central nervous system. This syndrome has an important negative impact on the daily life of affected subjects; however, it remains poorly studied, particularly in terms of pathophysiology, and its management is still not specific. Currently, the main pathophysiological hypothesis is an alteration of the afferences related to a dysfunction of the sensorimotor loop. An hypothesis is that this dysfunction could concern the level of tactile perception and that the damage to the distal light touch receptors could play a role in the pathophysiology. The protocol is based on the performance of tests that explore different aspects of light touch: passive, active, dynamic and static sensitivity.

Who can participate

Age range

18 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * No history of upper limb involvement * Confirmed diagnosis of segmental exclusion \> 3 months after injury (2 items assigned to 400 points) * Able to understand simple orders Exclusion Criteria: * Central neurological involvement after the initial or pre-existing injury * Truncal nerve damage * Presence of psychiatric pathology * Communication and/or comprehension disorders * Presence of other pathology that may lead to sensory disorders (complicated diabetes, ductal syndrome, ...)

Questions worth asking your doctor

Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.

1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?

Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.

Questions for the trial coordinator

The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.

1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?

A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.

What they're measuring

Difference in passive sensitivity discrimination orientation threshold between each hand in static condition.

Timeframe: once during the one-day evaluation session

Difference in passive sensitivity discrimination threshold between each hand in static condition.

Timeframe: once during the one-day evaluation session

Difference in passive sensitivity discrimination of pressure threshold between each hand in static condition.

Timeframe: once during the one-day evaluation session

Difference in passive sensitivity discrimination threshold between each hand in dynamic condition.

Timeframe: once during the one-day evaluation session

Trial details

NCT IDNCT05650398

SponsorUnion de Gestion des Etablissements des Caisses d'Assurance Maladie - Nord Est

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2025-02-15

View on ClinicalTrials.gov More Upper Limb Exclusion Syndrom trials

Plain-language summary

Who can participate

Age range

18 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

What they're measuring

Difference in passive sensitivity discrimination orientation threshold between each hand in static condition.

Timeframe: once during the one-day evaluation session

Difference in passive sensitivity discrimination threshold between each hand in static condition.

Timeframe: once during the one-day evaluation session

Difference in passive sensitivity discrimination of pressure threshold between each hand in static condition.

Timeframe: once during the one-day evaluation session

Difference in passive sensitivity discrimination threshold between each hand in dynamic condition.

Timeframe: once during the one-day evaluation session