CompletedNot Applicable

Effects of Radiofrequency Ablation of Posterior Nasal Nerves on Inflammatory Cytokines, Peak Nasal Inspiratory Flow, and Nasal Blood Flow in Patients With Chronic Rhinitis

United States17 participantsStarted 2023-01-10

Plain-language summary

The purpose of this study is to assess the effectiveness of radiofrequency ablation (RFA) of the posterior nasal nerve (PNN) in chronic rhinitis (CR) patients by comparing patient reflective total nasal symptom score (rTNSS) and nasal obstruction symptom evaluation (NOSE) , peak nasal inspiratory flow (PNIF) , and levels of Type 2 cytokines pre- and post-procedure.

Who can participate

Age range18 Years – 80 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * chronic rhinitis symptoms for at least 6 months (rhinorrhea, congestion, post-nasal drip) * poor response to medical management that was attempted for at least 4 weeks * a rTNSS score ≥6, as well as ≥2 for rhinorrhea, and ≥1 for congestion. Exclusion Criteria: * active sinusitis * rhinitis medicamentosa * recurrent and ongoing epistaxis * immunodeficiency as defined by an illness or a history of sinus surgery.

What they're measuring

Nasal Congestion as Assessed by the Peak Nasal Inspiratory Flow (PNIF)

Timeframe: Baseline

Nasal Congestion as Assessed by the Peak Nasal Inspiratory Flow (PNIF)

Timeframe: 4 weeks post intervention

Nasal Congestion as Assessed by the Peak Nasal Inspiratory Flow (PNIF)

Timeframe: 12 weeks post intervention

Interleukin-10 (IL-10)

Timeframe: Baseline

Interleukin-22 (IL-22)

Timeframe: Baseline

Interleukin-10 (IL-10)

Timeframe: 12 weeks post intervention

Interleukin-22 (IL-22)

Timeframe: 12 weeks post intervention

Trial details

NCT IDNCT05648565

SponsorThe University of Texas Health Science Center, Houston

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2024-02-20

Results submitted2025-02-18

View on ClinicalTrials.gov More Chronic Rhinitis trials

Plain-language summary

Who can participate

Age range18 Years – 80 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

What they're measuring

Nasal Congestion as Assessed by the Peak Nasal Inspiratory Flow (PNIF)

Timeframe: Baseline

Nasal Congestion as Assessed by the Peak Nasal Inspiratory Flow (PNIF)

Timeframe: 4 weeks post intervention

Nasal Congestion as Assessed by the Peak Nasal Inspiratory Flow (PNIF)

Timeframe: 12 weeks post intervention

Interleukin-10 (IL-10)

Timeframe: Baseline

Interleukin-22 (IL-22)

Timeframe: Baseline

Interleukin-10 (IL-10)

Timeframe: 12 weeks post intervention

Interleukin-22 (IL-22)

Timeframe: 12 weeks post intervention