Study of NM8074 in Adult C3 Glomerulopathy Patients

Inclusion Criteria: * Patients ≥ 18 and ≤ 65 years at the time of consent * Diagnosis of C3 Glomerulopathy as confirmed by C3 nephropathy in biopsy within 12 months prior to enrollment * Reduced serum C3 levels (defined as less than 0.85 x lower limit of the central laboratory normal range) at Screening * Patients with confirmed proteinuria * Willing and able to understand and complete informed consent procedures, including signing and dating the informed consent form (ICF), and comply with the study visit schedule * Women of child-bearing potential (WOCBP), defined as all women physiologically capable of becoming pregnant, must have a negative pregnancy test at screening and must agree to use highly effective methods of contraception during dosing and for 1 week after stopping of investigational drug * Males must agree to use contraceptives and refrain from donating sperm for the duration of the study * Patients must have documentation of previous vaccination or be willing to be vaccinated prior to dosing with NM8074. All patients will be vaccinated against Neisseria meningitidis, Streptococcus pneumoniae and Haemophilus influenzae according to the most current Advisory Committee on Immunization Practices (ACIP) recommendations. * Estimated glomerular filtration (eGFR) rate of ≤ 60 ml/min but ≥ 20 ml/min Exclusion Criteria: * Use of other investigational drugs at the time of enrollment * Patients with other renal diseases that would interfere with interpretation of the st…