The goal of the study is to examine multiple markers of anthropometrics, body composition, sarcopenia and frailty and compare them to dual energy X-ray absorptiometry (DXA) output, which is considered the current clinical gold-standard tool to measure body composition. The result of this study will provide detailed data regarding the nutrition and body composition within this Cystic Fibrosis population and also provide a baseline evaluation for use of these biomarkers in the future studies including evaluation of nutritional intervention. Further, the study will also include psychosocial and other patient-reported outcomes and medical contributors to understand their contributions to the nutritional failure in the adult advanced lung disease population. Finally, the study will evaluate both established and emerging nutritional and body composition parameters and link them to clinical outcomes in adults with CF across the spectrum of pulmonary function.
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Correlation between DXA lean mass index and BMI
Timeframe: Baseline and 1 year
Correlation between DXA lean mass index and mid-arm muscle circumference
Timeframe: Baseline and 1 year
Correlation between DXA lean mass index and hand-grip strength
Timeframe: Baseline and 1 year
Correlation between DXA lean mass index and the 6-minute walk distance traveled
Timeframe: Baseline and 1 year
Correlation between DXA lean mass index and the 1-minute sit-to-stand number of repetitions
Timeframe: Baseline and 1 year
Correlation between DXA lean mass index and Short Physical Performance Battery frailty score
Timeframe: Baseline and 1 year