The Possible Efficacy and Safety of L-carnitine and Biotin as Adjunctive Therapies in Children With Moderate Persistent Asthma

Inclusion Criteria: * Children with moderate persistent asthma * Age range of 8-\< 18 years old * Both sex Exclusion Criteria: * Children with any pulmonary or chronic systemic diseases other than asthma (cystic fibrosis, bronchiectasis, tuberculosis, diabetes mellitus, and liver disease). * Children with immunodeficiency. * Children with thyroid disorder. * Children with recent infection (especially pneumonia), surgery, anesthesia. * Children having clinical evidence of any heart renal and hepatic diseases. * Children having cystic fibrosis or congenital respiratory disease. * Children having chronic diarrhea and mal-absorption. * Children having clinical evidence of malnutrition. * Children on medications that could interfere with L-carnitine level including antibiotics use. (particularly ampicillins) and anti- convulsing particularly valoproic acid.