Liquid Biopsy in High-grade Gliomas and Meningiomas

Inclusion Criteria: * Age ≥ 18 years * Finding, on an MRI scan of the brain with gadolinium, of a brain lesion compatible with a primary brain tumor, intra- or extra-axial, suspected for a high-grade glioma or a high-grade meningioma, manifested with new onset neurological symptoms * Clinical indication to perform a biopsy or surgical resection of the lesion * Karnofsky Performance Status (KPS) ≥ 60 * Signature of informed consent Exclusion Criteria: * Absolute contraindications to magnetic resonance imaging or to the administration of gadolinium (e.g. patients with pacemakers or other non-magneto-compatible devices) * Known positivity for HIV, HCV or HBV * There are clinical, biological or instrumental data suggesting that the brain lesion is non-neoplastic in nature (e.g., abscess, vascular malformation, inflammatory disease of the Central Nervous System) * Women who are pregnant or breastfeeding