CompletedNot Applicable

A Neurobiological Model of Anhedonia

United States60 participantsStarted 2020-02-19

Plain-language summary

The purpose of this research study is to better understand anhedonia in Major Depressive Disorder by investigating the reward-related neural and inflammatory correlates.

Who can participate

Age range18 Years – 65 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Current diagnosis of MDD based on the MINI International Neuropsychiatric Interview (MINI) * For treatment resistant depression participants: unsuccessful treatment with at least 2 types or doses of antidepressant medication treatment * Right-handed * Capacity for informed consent * Score a 9 or higher on the MADRS Exclusion Criteria: * Comorbid Bipolar Disorder * Substance use disorder in the last 12 months * Schizophrenia, and other psychotic disorders * Comorbid illness such as endocrinological illness (e.g. Cushing's disease) rheumatologic illness (e.g., systemic Lupus erythematosus, current treatment with glucocorticoids), and autoimmune diseases (e.g. psoriasis) * Pregnancy * Daily NSAID or aspirin use and any metallic implant * Visual/Hearing Impairments that would keep participant from being able to complete tasks

What they're measuring

Basal inflammatory marker assessment

Timeframe: 1 hour

Behavior during reward-based task - Monetary Incentive Delay Task

Timeframe: 30 minutes

Behavior during reward-based task - Reward Probabilistic Reversal Learning Task

Timeframe: 30 minutes

Blood oxygen level dependent (BOLD) activation during reward-based tasks

Timeframe: 1 hour

Trial details

NCT IDNCT05629520

SponsorMilton S. Hershey Medical Center

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2024-07-30

View on ClinicalTrials.gov More Anhedonia trials