Anti-inflammatory Drugs and Serum Prostate-Specific Antigen Test

Inclusion Criteria: * Male patients age between 18-80 years old with a screening PSA \> 3 ng/ml being considered for additional diagnostic testing (e.g., MRI, biopsy) * Normal digital rectal examination within the past two years. A documented normal digital rectal examination by another physician or advanced practice provider (NP, PA, etc) is acceptable. * No clinical symptoms concerning for acute urinary tract infection (e.g. dysuria, malodorous urine, positive urine culture) Exclusion Criteria: * History of hypersensitivity or allergy to ibuprofen or NSAIDs. * History of peptic ulcer disease, GI bleeding or NSAIDs induced GI adverse events * Known bleeding disorders * Known severe chronic kidney disease: eGFR \< 30 mL/min/1.73 m2 * Heart failure, significant heart disease * Poorly controlled hypertension * Active urinary tract infections or bacteriuria * Concomitant use of 5-alpha reductase inhibitors (finasteride, dutasteride) unless patient has been taking it for at least 6 months * Known prostate cancer or underwent prostate MRI or biopsy in the last year * Urinary tract instrumentation in the past 6 weeks (catheter, cystoscopy) * Concomitant anti-inflammatory or steroidal drugs * Concomitant dual-antiplatelet or anticoagulant therapy use except aspirin 81 mg alone * Know history of severe liver disease determined by abnormal liver function tests (elevated AST or ALT \> 3X ULN based on exiting history or labs) * Any other medical contraindication to NSAIDs