Disulfiram for Treatment of Retinal Degeneration

Inclusion Criteria: Age ≥18 years Only those with a clinical diagnosis of inherited retinal degeneration. When available, supporting genetic diagnosis form a CLIA approved lab will be further considered for inclusion. Only one eye per subject should be identified as the study eye. The study eye must meet the following criteria: * Best corrected ETDRS visual acuity letter score ≥ 70 (i.e., 20/40 or better) within 30 days of enrollment. * Goldmann visual field exhibiting constriction of visual fields to 10 degrees centrally * Able and willing to provide informed consent * Willing and able to abstain from alcohol consumption for the duration of the study and the 2 weeks preceding it and 2 weeks following the study end point Liver function values that fall in the normal range as specified below: * Alanine transaminase (ALT): less than 40 IU/L * Aspartate transaminase (AST): less than 40 IU/L * Alkaline phosphatase (ALP): less than 300 IU/L * Albumin (Alb): less than 50 g/L * Total Protein: less than 80 g/L * Total Bilirubin: less than 30 umol/L Exclusion Criteria: * A condition that, in the opinion of the investigator, would preclude participation in the study, e.g., alcohol dependence, cardiovascular disease, hepatitis. * Individuals with a history of diabetes mellitus * Individuals with a history of psychosis * Individuals with hypothyroidism * Individuals with hypersensitivity to thiuram derivatives causing rubber contact dermatitis * Those on anticoagulant therapy or o…