Tofatib Treatment for IgG4-related Disease

Inclusion Criteria: * It meets the 2019 ACR/EULAR classification diagnostic criteria for IgG4 related diseases, and is an active IgG4-RD, defined as an IgG4-RD RI score ≥ 3 points when screening Exclusion Criteria: * 1\. IgG4 related diseases endangering organ function or life; 2\. Only Mikulicz disease, no other internal organs involved; 3\. People with history of thrombotic disease or high risk of thrombosis; 4\. Have a history of malignant tumor; 5\. Active infection; 6\. Pregnant or lactating women;