A bivalent Typhoid and Paratyphoid A conjugate investigational vaccine aimed to prevent both typhoid and paratyphoid enteric fever in infants and older age groups has been developed by GlaxoSmithKline (GSK). The purpose of this first-time-in-human study is to evaluate the safety and immunogenicity profile of a low and a full dose of the investigational vaccine, formulated with or without adjuvant, administered in 2 doses, 24 weeks apart, in healthy adults 18 to 50 years of age in Europe.
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Number of Participants With Solicited Administration-site Events After the First Vaccination
Timeframe: From Day 1 to Day 7
Number of Participants With Solicited Administration-site Events After the Second Vaccination
Timeframe: From Day 169 to Day 175
Number of Participants With Solicited Systemic Events After the First Vaccination
Timeframe: From Day 1 to Day 7
Number of Participants With Solicited Systemic Events After the Second Vaccination
Timeframe: From Day 169 to Day 175
Number of Participants With Unsolicited Adverse Events (AEs) After the First Vaccination
Timeframe: From Day 1 to Day 28
Number of Participants With Unsolicited Adverse Events After the Second Vaccination
Timeframe: From Day 169 to Day 196
Number of Participants With Any Serious Adverse Events (SAEs)
Timeframe: From Day 1 to Day 197
Number of Participants With AEs/SAEs Leading to Withdrawal From the Study
Timeframe: From Day 1 to Day 197
Number of Participants With SAEs Leading to Withholding Further Study Intervention Administration
Timeframe: From Day 1 to Day 197
Number of Participants With AEs Leading to Withholding Further Study Intervention Administration
Timeframe: From Day 1 to Day 197
Number of Participants With Deviations From Normal or Baseline Values of Haematological, Renal, and Hepatic Panel Test Results at Day 8
Timeframe: At Day 8 compared to Day 1 (Baseline)
Number of Participants With Deviations From Normal or Baseline Values of Haematological, Renal, and Hepatic Panel Test Results at Day 176
Timeframe: At Day 176 compared to Day 169 (Baseline)