A bivalent Typhoid and Paratyphoid A conjugate investigational vaccine aimed to prevent both typhoid and paratyphoid enteric fever in infants and older age groups has been developed by GlaxoSmithKline (GSK). The purpose of this first-time-in-human study is to evaluate the safety and immunogenicity profile of a low and a full dose of the investigational vaccine, formulated with or without adjuvant, administered in 2 doses, 24 weeks apart, in healthy adults 18 to 50 years of age in Europe.
Age range
18 Years – 50 Years
Sex
ALL
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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
Number of Participants With Solicited Administration-site Events After the First Vaccination
Timeframe: From Day 1 to Day 7
Number of Participants With Solicited Administration-site Events After the Second Vaccination
Timeframe: From Day 169 to Day 175
Number of Participants With Solicited Systemic Events After the First Vaccination
Timeframe: From Day 1 to Day 7
Number of Participants With Solicited Systemic Events After the Second Vaccination
Timeframe: From Day 169 to Day 175
Number of Participants With Unsolicited Adverse Events (AEs) After the First Vaccination
Timeframe: From Day 1 to Day 28
Number of Participants With Unsolicited Adverse Events After the Second Vaccination
Timeframe: From Day 169 to Day 196
Number of Participants With Any Serious Adverse Events (SAEs)
Timeframe: From Day 1 to Day 197
Number of Participants With AEs/SAEs Leading to Withdrawal From the Study
Timeframe: From Day 1 to Day 197
Number of Participants With SAEs Leading to Withholding Further Study Intervention Administration
Timeframe: From Day 1 to Day 197
Number of Participants With AEs Leading to Withholding Further Study Intervention Administration
Timeframe: From Day 1 to Day 197
Number of Participants With Deviations From Normal or Baseline Values of Haematological, Renal, and Hepatic Panel Test Results at Day 8
Timeframe: At Day 8 compared to Day 1 (Baseline)
Number of Participants With Deviations From Normal or Baseline Values of Haematological, Renal, and Hepatic Panel Test Results at Day 176
Timeframe: At Day 176 compared to Day 169 (Baseline)