Exenatide for Smoking Cessation and Prevention of Weight Gain

Inclusion Criteria: * Be willing and able to sign and date an informed consent form, willing to comply with all study procedures, and be available for the duration of the study * Male or female, 18-75 years of age * Have been smoking ≥5 cigarettes per day for at least 1 year and provide positive cotinine test * Desire to quit smoking (defined as "intend to quit within one month") * Have HbA1C levels between 5.7 and 6.4% and/or a body mass index of ≥25 kg/m2 * Have vital signs as follows: resting pulse between 50 and 95 bpm, BP between 90-150 mmHg systolic and 45-95 mmHg diastolic * Have hematology and chemistry laboratory tests that are within reference limits (±10%), with the following exception: pancreatic tests (lipase and amylase) must be within normal limits * Agree (if the subject is female and of child-bearing potential) to use at least one of the following methods of birth control from time of the first administration of the study medication to at least 7 days post the last dose of the study medication, unless the partner is surgically sterile (underwent vasectomy): oral contraceptives, contraceptive sponge, patch, double barrier (diaphragm/spermicidal or condom/spermicidal), intrauterine contraceptive system, etonogestrel implant, medroxyprogesterone acetate contraceptive injection, hormonal vaginal contraceptive ring, or complete abstinence from sexual intercourse. * Women of child-bearing potential must provide negative urine pregnancy tests prior to randomization…