Local and Systemic Antimicrobials in Non-surgical Periodontal Therapy (NCT05608564) | Clinical Trial Compass
CompletedNot Applicable
Local and Systemic Antimicrobials in Non-surgical Periodontal Therapy
Serbia38 participantsStarted 2023-01-17
Plain-language summary
The main treatment of every patient with periodontitis is non-surgical periodontal treatment (NSPT) with the ultimate goal to arrest inflammation. Given the biofilm microorganisms associated etiology of the periodontitis, NSPT can be combined with adjunctive antimicrobial therapy. Hence, this randomized clinical trial aims to compare the clinical and microbiological effectiveness and relative expression levels (REL) of proinflammatory cytokines tumor necrosis factor-alpha (TNF-Ξ±) and interleukin-17 (IL-17) between local and systemic antibiotics as adjunctive therapy to NSPT in patents with periodontitis stage 3.
Who can participate
Age range18 Years β 45 Years
SexALL
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Inclusion criteria
β. Both sexes, 18 - 45 years old
β. Willingness to participate in the research, comply with all the study protocols, and sign an informed consent;
β. Active periodontitis stage II and III according to the criteria of the 2017 World Workshop on the Classification of Periodontal and Peri-Implant Diseases and Conditions;
β. Non-smokers and light smokers (up to 10 cigarettes per day).
Exclusion criteria
β. Presence of systemic diseases known to affect the tooth-supporting apparatus and bone metabolism (such as uncontrolled diabetes mellitus, cancer, immunodeficiency, metabolic bone diseases);
β. Patients receiving an immunosuppressive, anti-resorptive, or anti-inflammatory therapy;
β. Allergy to penicillin;
β. Patients who had undergone periodontal therapy within the last 6 months;
β. Use of local and/or systemic antimicrobial agents within the last 6 months;