RecruitingNot Applicable

Randomized Assessment of TcMS for VT Storm

United States60 participantsStarted 2023-05-22

Plain-language summary

Three-arm randomized clinical trial comparing two strategies of TcMS to sham stimulation in patients with VT storm. The hypothesis of the study is that TcMS will reduce the burden of VT in the 24 hours after randomization compared to sham stimulation and that TcMS with theta burst stimulation (TBS) will be more effective at reducing VT burden than low frequency TcMS.

Who can participate

Age range18 Years

SexALL

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Inclusion Criteria: * ≥3 episodes of sustained VT or appropriate ICD therapies within 24 hours despite the use of at least one antiarrhythmic drug Exclusion Criteria: * Plan for catheter ablation of VT in the next 24 hours * Pregnancy * Contraindication to TcMS (i.e. implantable ventricular assist device, metal implanted in the head or neck \[except the mouth\], implanted medication pumps, cochlear implant, implanted brain stimulator, ocular implant, history of malignancy in the neck)

What they're measuring

VT Burden (24 hours)

Timeframe: 24 hours after randomization

Trial details

NCT IDNCT05599022

SponsorUniversity of Pennsylvania

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2028-07

Contact for this trial

Timothy Markman

215-615-4332 timothy.markman@pennmedicine.upenn.edu

View on ClinicalTrials.gov More Ventricular Tachycardia trials