CompletedNot Applicable

Effect of Remote Ischemic Conditioning on Cerebral Hemodynamics in Patients After Intravenous Thrombolysis (RICCH-IVT)

China100 participantsStarted 2023-04-01

Plain-language summary

The purpose of this study is to determine the effect of remote ischemic conditioning on cerebral hemodynamics in patients after intravenous thrombolysis

Who can participate

Age range18 Years – 80 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion criteria

✓. age ≥ 18 and \< 80 years, both sexes;
✓. a clear clinical diagnosis of acute ischemic stroke and treatment with standard rt-PA (0.9 mg/kg) IVT within 4.5 h of stroke onset;
✓. pre-onset modified Rankin Scale (mRS) score ≤1;
✓. baseline National Institute of Health Stroke Scale (NIHSS) score ≥5 and ≤25;
✓. Glasgow Coma Scale score ≥8.

Exclusion criteria

✕. having received bridging therapy (IVT plus mechanical thrombectomy);
✕. previous history of atrial fibrillation or electrocardiographic evidence of atrial fibrillation;
✕. contraindications to RIC treatment or previous RIC treatment or similar treatment;
✕. pregnancy or breastfeeding;
✕. life expectancy of ≤3 months or inability to complete the study for other reasons;
✕. unwillingness to be followed up or poor treatment compliance or participation in other clinical studies;
✕. had insufficient bilateral temporal bone windows for insonation of the middle cerebral artery.

What they're measuring

Cerebral autoregulation parameter

Timeframe: 1-10 days

Trial details

NCT IDNCT05598658

SponsorYi Yang

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2024-01-12

View on ClinicalTrials.gov More Remote Ischemic Conditioning trials