Monthly Versus Daily Buprenorphine Formulations for Treatment of Opiate Use Disorder

Inclusion Criteria: * Ages 18 to 65 years old * OAT indicated for moderate- to severe-OUD * Attend a RAAM clinic in the North Simcoe Muskoka Local Health Integrated Network for opiate substitution treatment * Successfully completed induction and stabilization OAT with Suboxone® tablet or film defined as receiving 8mg/2mg to 24mg/6mg of Suboxone® for ≥7 days with no evidence of allergic reaction to Suboxone®, Clinical Opiate Withdrawal Scale (COWS) score ≤12 (scale:0-48) for ≥24 hours, and Opiate Craving Visual Analog Scale (VAS) score ≤20 (scale:0-100)) for ≥24 hours * Must have an active Ontario Health Insurance Plan number * Must have a telephone that can receive calls, text messages or emails * Must have drug insurance coverage for either medication for duration of study or demonstrate ability to pay for the drug out-of-pocket Exclusion Criteria: * Receiving any investigational drug for OUD in previous 4 weeks * Congenital long QTc syndrome or QTc prolongation at baseline by electrocardiogram (QTc ≥450 milliseconds in men and QTc ≥470 milliseconds in women) * Pregnant or lactating women * Women of childbearing potential who are not using an effective and reliable method of contraception