Safety and Efficacy of Radiation Plus TACE and Lenvatinib in Advanced HCC With PVTT (NCT05592197) | Clinical Trial Compass
WithdrawnNot Applicable
Safety and Efficacy of Radiation Plus TACE and Lenvatinib in Advanced HCC With PVTT
Stopped: This is a sub-study of another one.
China0Started 2018-10-01
Plain-language summary
This is a multicentri prospective cohort study to investigate the safety and efficacy of external beam radiation (RT) combined with transarterial chemoembolization (TACE) and lenvatinib vs TACE and lenvatinib in the treatment of advanced hepatocellular carcinoma (HCC) with portal vein tumor thrombus (PVTT).
Who can participate
Age range18 Years – 75 Years
SexALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion criteria
✓. age 18-75 years;
✓. histologically or cytologically or clinically confirmed diagnosis of HCC;
✓. presenting with PVTT and at least one measurable intrahepatic lesion on the basis of modified Response Evaluation Criteria in Solid Tumors (mRECIST); an intrahepatic lesion consisting of a single tumor (≤ 10.0 cm) or multiple tumors (≤ 3 foci) with the tumor burden \< 50%;
✓. Eastern Cooperative Oncology Group (ECOG) performance status score of 0 or 1;
✓. Child-Pugh class A or B;
✓. life expectancy of at least 3 months;
✓. satisfactory blood, liver, and kidney function parameters. The acceptable blood, liver, and kidney parameters were (1) neutrophil count ≥ 1.5 × 109/L; (2) platelet count ≥ 60 × 109/L; (3) hemoglobin concentration ≥ 90 g/L; (4) serum albumin concentration ≥ 30 g/L; (5) bilirubin ≤ 50 μmol/L; (6) AST and ALT \< 5 × upper limit of normal (ULN) and alkaline phosphatase \< 4 × ULN; (7) extended prothrombin time \< 6 seconds of ULN; and (8) serum creatinine \< 1.5 × ULN.
Exclusion criteria
✕. history of liver and adjacent tissue radiation;
✕. medical history of hepatic decompensation, such as hepatic encephalopathy and esophageal or gastric variceal bleeding;