Advanced stages of the response to life-threatening infection, severe trauma, or other physiological insults often lead to exhaustion of the homeostatic mechanisms that sustain normal blood pressure and oxygenation. These syndromic presentations often meet the diagnostic criteria of sepsis and/or the acute respiratory distress syndrome (ARDS), the two most common syndromes encountered in the intensive care unit (ICU). Although critical illness syndromes, such as sepsis and ARDS, have separate clinical definitions, they often overlap clinically and share several common injury mechanisms. Moreover, there are no specific therapies for critically ill patients, and as a consequence, approximately 1 in 4 patients admitted to the ICU will not survive. The purpose of this observational study is to identify early patient biologic factors that are present at the time of ICU admission that will help diagnose critical illness syndromes earlier, identify who could benefit most from specific therapies, and enable the discovery of new treatments for syndromes such as sepsis and ARDS.
Age range
18 Years
Sex
ALL
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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
Risk of developing nosocomial infections during ICU admission
Timeframe: Assessed daily until discharge from ICU, through study completion, an average of 1 year
Severity of illness measured by APACHE score
Timeframe: At the time of ICU admission
Severity of illness measured by SOFA score
Timeframe: At the time of ICU admission
Severity of illness measured by MODS score
Timeframe: At the time of ICU admission
Change in severity of illness measured by APACHE score
Timeframe: From the time of ICU admission, assessed daily until death or discharge from ICU, up to 12 months
Change in severity of illness measured by SOFA score
Timeframe: From the time of ICU admission, assessed daily until death or discharge from ICU, up to 12 months
Change in severity of illness measured by MODS score
Timeframe: From the time of ICU admission, assessed daily until death or discharge from ICU, up to 12 months
Hospital disposition
Timeframe: Determined at the time of discharge from the hospital, through study completion, an average of 1 year