CompletedNot Applicable

Determination of Liquid Flavor and Nicotine Form Outcomes

United States13 participantsStarted 2023-07-21

Plain-language summary

The purpose of this research study is to find out how different types of electronic cigarette/vape e-liquids with differing sweetness and forms of nicotine affect blood nicotine levels, use behavior (how people puff), and how people feel.

Who can participate

Age range

18 Years – 65 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * healthy (determined by self-report) * between the ages of 18-65 * willing to provide informed consent * use cigarettes, e-cigarettes, or both * able to attend the lab and abstain from tobacco/nicotine as required and must agree to use designated products according to study protocol Exclusion Criteria: * women if they are breast-feeding or test positive for pregnancy (by urinalysis) at screening * existence of any condition contraindicated for this study protocol as determined by study leadership Some study details about the eligibility criteria are purposely omitted at this time to preserve scientific integrity. Full details will be posted at the conclusion of the study.

Questions worth asking your doctor

Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.

1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?

Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.

Questions for the trial coordinator

The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.

1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?

A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.

What they're measuring

Change in plasma nicotine concentration

Timeframe: Baseline (approx 90 min after session start) to after final product usage (up to 165 min)

Puff volume

Timeframe: Through the final product use (up to 165 min)

Puff duration

Timeframe: Through the final product use (up to 165 min)

Challenge paradigm latency

Timeframe: at the end of the challenge paradigm, approx. 165 min

Challenge paradigm puffs

Timeframe: at the end of the challenge paradigm, approx. 165 min

Trial details

NCT IDNCT05587504

SponsorVirginia Commonwealth University

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2024-07-24

View on ClinicalTrials.gov More Electronic Cigarettes trials

Who can participate

Age range

18 Years – 65 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

What they're measuring

Change in plasma nicotine concentration

Timeframe: Baseline (approx 90 min after session start) to after final product usage (up to 165 min)

Puff volume

Timeframe: Through the final product use (up to 165 min)

Puff duration

Timeframe: Through the final product use (up to 165 min)

Challenge paradigm latency

Timeframe: at the end of the challenge paradigm, approx. 165 min

Challenge paradigm puffs

Timeframe: at the end of the challenge paradigm, approx. 165 min