Vacuum Assisted Sclerotherapy Performed by Catheter

Inclusion Criteria: * Age: ≥18 years old * Weight \>45 kg * Asymptomatic or presence of at least one of the following symptoms: pain, heaviness, tiredness, itching, night cramps, restlessness, general discomfort, swelling. * GSV standing diameter between 4 and 12 mm along the whole veins (measured by Duplex ultrasound) * Willingness to undergo follow-up visits * Ability to understand scope, content and risks of the study, and provide informed consent to participation Exclusion Criteria: * Contraindications for endovascular procedures (fever, infectious processes, tumor diseases, hemorragic diathesis) * Any disease or condition contraindicating sclerotherapy treatment * Peripheral symptomatic arterial pathology (ankle brachial index ABI \<0.80) * History or suspect of Deep Venous Thrombosis (DVT) or Superficial Venous Thrombosis of Great Saphenous Vein (SVT of GSV) * GSV standing diameter \> 12 mm for vein segments longer than 3 cm or diameter \< 4 mm for segments longer than 5 cm * Caprini score \>10 * Pregnancy and breastfeeding * Previous treatments of venous pathologies in the leg (excluding telangiectasis and reticular venulas) * Allergy to sclerosant agent * Participation in another clinical trial