V/Q Matching Variations With PEEP in ARDS According to Compliance-based Phenotypes (France)

Inclusion criteria: * intubated patients with moderate and severe ARDS (Berlin definition, PaO2/FiO2 ≤200 mmHg at PEEP 5 cmH2O) * undergoing deep sedation * on controlled mechanical ventilation * between 24 hours and 5 days after intubation. Exclusion criteria: * age \<18 years old; pregnancy * patient undergoing legal protection * contra-indications to EIT (e. g. severe chest trauma or wounds) * pneumothorax; patient undergoing ECMO * patient with BMI ≥35 kg/m2 * hemodynamic instability with MAP \<60 mmHg despite vasopressors.