CompletedNot Applicable

Respiratory Muscles Electromyography in Patients With Covid-19

Brazil74 participantsStarted 2021-02-25

Plain-language summary

This research was characterized as a cross-sectional observational study, following the recommendations of the STROBE instrument. Therefore, it was conducted in the Intensive Care Unit of Otávio de Freitas Hospital (HOF) in Recife/PE, with patients over 18 years old who had a clinical diagnosis of COVID-19, using two methods of oxygen therapy (Nasal Oxygen Therapy) and (non-rebreather mask). Consequently, clinical evaluations were performed regarding the disease, severity of COVID-19, perception of respiratory effort, and electromyography of respiratory muscles. 1. Leading Question: How does the recruitment pattern of diaphragmatic and extradiaphragmatic muscles in patients with acute hypoxemia caused by COVID-19 behave when assessed through EMGs, considering the SpO2/FiO2 ratio as the analysis parameter? 2. Leading Question: Is there a relationship between the respiratory work estimated by electromyographic activity of diaphragmatic and extradiaphragmatic muscles in patients with acute hypoxemia due to COVID-19 and the parameters of respiratory frequency and levels of acute hypoxemia measured by the SpO2/FiO2 ratio? The rationale for this study is that the COVID-19 pandemic has caused significant impacts on global public health due to the high volume of respiratory complications in the face of a limited supply of healthcare resources, consequently leading to high mortality. Complications are initially manifested by acute hypoxemia associated with COVID-19 infection, sometimes silent upon visual inspection or using less sensitive methods. This complicates the management of compensatory respiratory work for hypoxemia, even with oxygen therapy support. Respiratory muscle recruitment involves aspects of inspiratory effort and ventilatory mechanics. Recognizing the presence and recruitment pattern of muscles involved in a timely manner can contribute to the clinical management success rate of individuals affected by respiratory dysfunction associated with COVID-19, especially at different levels of acute hypoxemia. Surface electromyography is a non-invasive, low-risk tool compatible with the analysis of respiratory muscle recruitment patterns. However, there are no studies describing this pattern in COVID-19 patients, serving as a basis for personalized therapeutic strategies.

Who can participate

Age range18 Years – 90 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion criteria: * Both genders * Age ≥ 18 years * Confirmed diagnosis for COVID-19 considering its positivity through the RT-PCR test * Patients who required low-flow oxygen therapy (nasal oxygen catheter or non-rebreathing mask) * Hemodynamic stability (heart rate between 60 - 149 bpm, systolic blood pressure ≤149/89 mmHg or diastolic ≥ 90/60 mmHg at the time of collection) * Body Mass Index ≤ 30 kg/m². Exclusion criteria: * Anxiety and psychomotor agitation * Postural deformities (hyperlordosis, hyperkyphosis, lateral inclinations and antalgic postures) * Patients with chronic lung disease or diaphragmatic disorders * Undergoing surgical procedures on the spine * Neurological diseases that affect myoelectric conduction * Trauma or musculoskeletal injuries to the rib cage or respiratory muscles * Use of tracheostomy tubes * History of use of invasive mechanical ventilation during hospitalization (diagnosed and previously described in the electronic medical record) * Those who were using sedatives and bronchodilators, as well as a reduction in SpO2 during signal acquisition at the time of collection.

What they're measuring

Degree of dyspnea

Timeframe: 10 minutes

Level of activation of respiratory muscles

Timeframe: 10 minutes

Trial details

NCT IDNCT05572853

SponsorUniversity of Pernambuco

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2022-12-30