Clinical Study to Evaluate Adaptos®Ortho Wedge Bone Graft Substitute in High Tibial Osteotomy

Inclusion Criteria: * Subjects aged between 25 and 65 years at the time of enrolment. * Subjects that sign and date a written, informed consent form (ICF) prior to the initiations of any trial procedures, after the nature of the trial has been explained according to regulatory requirements. * Subjects who can comply with trial procedures and are available for the duration of the trial. * Accepts all treatment arms. * Subjects with varus malalignment of the knee, scheduled to have medial open-wedge high tibial osteotomy (OWHTO) but are otherwise in good health at the time of entry into the trial as determined by medical history, physical/clinical examination, and clinical judgement of the investigator. * Full knee range of motion (ROM) (at least 5-120 degrees). * Preoperatively planned osteotomy 5-13 degrees of the proximal tibia done based on the weight-bearing x-ray of the full leg in AP view using Miniaci Method. * Body Mass Index (BMI) ≤30 Exclusion Criteria: * Previous knee area osteotomy or lower limb arthroplasty of the investigational knee. * Presence of the following unfavourable conditions: osteoporosis, infectious/inflammatory joint disease, infections, or inflammation in the operation area, clinically relevant, not medically managed, severe acute or chronic medical illness, immune-compromised, metabolic/systemic bone disorder, untreated malignant myeloma, Burkitt's lymphoma, lateral osteoarthritis (Kellgren-Lawrence grade \>1) * Smoking or use of other nicotine …