Stopped: Sponsor decision.
The purpose of this study is to measure safety and efficacy of oral belumosudil in Black or African American, American Indian or Alaska Native, and Native Hawaiian or Other Pacific Islander male and female participants with cGVHD who have previously been treated with at least 2 prior lines of systemic therapy aged 12 years and above. The duration of participants participation will be up to 4 weeks for screening, treatment until clinically significant progression of disease, and 4 weeks of safety follow-up, and then long-term follow-up every 12 weeks.1 Cycle = 28 days.
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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Number of participants with treatment emergent adverse events and serious adverse events
Timeframe: Up to approximately 48 months
Number of participants with clinically significant laboratory abnormalities
Timeframe: Up to approximately 12 months
Change from baseline in systolic and diastolic blood pressure
Timeframe: Baseline; up to approximately 12 months
Change from baseline in heart rate
Timeframe: Baseline; up to approximately 12 months
Change from baseline in corrected QT interval using Fridericia's formula (QTc[F])
Timeframe: Baseline; up to approximately 12 months
Overall Response Rate (ORR)
Timeframe: Up to approximately 12 months