A Healthy Volunteer Study Evaluating the the Safety, Tolerability, and Pharmacokinetics of RT234 (NCT05567367) | Clinical Trial Compass
CompletedPhase 1
A Healthy Volunteer Study Evaluating the the Safety, Tolerability, and Pharmacokinetics of RT234
Australia31 participantsStarted 2018-07-31
Plain-language summary
The objective of this two part study was to demonstrate safety, tolerability, and pharmacokinetics of RT234 in healthy volunteers.
This study is also known as Vardenafil Inhaled for Pulmonary Arterial Hypertension PRN Phase 1 (VIPAH-PRN 1) study
Who can participate
Age range18 Years – 45 Years
SexALL
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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion criteria
✓. Healthy male or female, 18 to 45 years of age (inclusive at time of informed consent)
✓. Normal heart, lung, kidney, and liver function based on physical examination
✓. Systolic blood pressure of 100-145 mmHg, diastolic blood pressure of 50-90 mmHg, and a resting heart rate of 40-100 bpm at Screening
✓. A body mass index (BMI) of ≤18 to ≥30 kg/m2 at Screening
✓. Must be a non-smoker or ex-smoker with less than a 5-pack year history of smoking (including the use of electronic cigarettes) and have ceased smoking ≥1 year prior to Screening; or a social smoker (defined as less than 10 cigarettes in the previous 12 months)
Exclusion criteria
✕. Has serum transaminase (i.e., alanine aminotransferase \[ALT\], aspartate aminotransferase \[AST\], or gamma-glutamyl transferase \[GGT\]) levels greater than three times the upper level of normal
✕. Abnormal orthostatic vital signs (at screening) defined as a decrease of ≥20 mmHg in systolic blood pressure and/or a decrease of ≥10 mmHg in diastolic blood pressure and/or \>25 bpm increase in heart rate within 3 minutes of standing, or with symptoms of light-headedness, dizziness, or fainting upon standing.
✕. History of hypotension including fainting, syncope, orthostatic hypotension, and/or vasovagal reactions
✕. History of retinitis pigmentosa
✕. Vision loss due to non-arteritic anterior ischemic optic neuropathy (NAION) or other optic perfusion impairment
What they're measuring
1
Number of participants with treatment related adverse events as assessed by CTCAE v5.0