Clinical Trial of Low-dose Radiation Therapy in Patients With Knee Osteoarthritis (LoRD-KNeA Trial)

Inclusion Criteria: * Age 50-85 years old * Kellgren-Lawrence grade 2-3 and diagnosed as a patient with primary knee osteoarthritis according to the ACR knee OA diagnostic criteria * Patients with VAS 40 or higher when walking, with or without medication at the time of screening * Patients who have VAS 50 or more and 90 or less when walking at the baseline * Among patients who were previously taking analgesic drugs at the time of screening, those with an increase in pain of 10 points or more at the baseline * Patients who do not want to take non-narcotic analgesics, those who have failed to control their pain due to the use of non-narcotic analgesics, or candidates for invasive treatment (intra-articular injection, arthroplasty, etc.) * A person who has a will to discontinue all pain medications except for rescue medications throughout screening, baseline, and clinical trials related to knee arthritis * A person who gives consent to use an approved contraceptive method from screening to 3 months after the end of the clinical trial * A person who understands the eligibility requirements for the study and has signed the consent form Exclusion Criteria: * A history of knee irradiation in the past * Patients participating in other degenerative arthritis clinical trials * Kellgren-Lawrence grade 4 * A history of malignancy within the last 5 years * A history of knee or hip surgery in the past * Patients who have received systemic steroid treatment or intra-articular steroid/hya…