CompletedNot Applicable

Cardiopulmonary Exercise Testing Parameters' Variability in Hemodialysis Patients.

Greece28 participantsStarted 2021-12-01

Plain-language summary

Chronic kidney disease (CKD), especially end-stage kidney disease (ESKD), is associated with increased risk for cardiovascular events and all-cause mortality. Exercise intolerance as well as reduced cardiovascular reserve are extremely common in patients with CKD. Cardiopulmonary exercise testing (CPET) is a non-invasive, dynamic technique that provides an integrative evaluation of cardiovascular, pulmonary, neuropsychological and metabolic function during maximal or submaximal exercise, allowing the evaluation of functional reserves of these systems. CPET is currently considered to be the gold-standard for identifying exercise limitation and differentiating its causes. It has been widely used in several medical fields for risk stratification, clinical evaluation and other applications. However, the use of CPET in assessment of exercise intolerance in everyday nephrology practice is limited. Hence, this is the first study possible differences in CPET's parameters during long and short interdialytic intervals in hemodialysis patients.

Who can participate

Age range18 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Hemodialysis patients aged \>18 years. * Patients with a total duration of hemodialysis \>3 months. * Patients enrolled in a dialysis program that includes three sessions per week. * Hemodialysis patients who are capable of exercising on a cycle ergometer. * Hemodialysis patients who are capable of understanding and providing written, signed consent to participate in the study Exclusion Criteria: Absolute and relative contraindications for performing CPET according to the American Thoracic Society (ATS) and the American College of Chest Physicians (ACCP), such as * Acute myocardial infarction (3-5 days) * Unstable angina * Uncontrolled arrhythmias causing symptoms or haemodynamic compromise * Syncope * Active endocarditis * Acute myocarditis or pericarditis * Symptomatic severe aortic stenosis * Uncontrolled heart failure * Acute pulmonary embolus or pulmonary infarction * Thrombosis of lower extremities * Suspected dissecting aneurysm * Uncontrolled asthma * Pulmonary oedema * Acute non-cardiopulmonary disorder that may affect exercise performance or be aggravated by exercise (ie, infection, renal failure, thyrotoxicosis) * Mental impairment leading to inability to cooperate * Orthopaedic impairment that compromises exercise performance * Electrolyte abnormalities * Advanced or complicated pregnancy...

What they're measuring

Difference in VO2peak (ml/min/kg)

Timeframe: Two-week time frame between the study evaluation time points (before dialysis session after the long interdialytic interval versus before dialysis session after the short interdialytic interval)

Difference in VO2peak ((ml/min)

Trial details

NCT IDNCT05557929

SponsorAristotle University Of Thessaloniki

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2023-07-28

View on ClinicalTrials.gov More Chronic Kidney Disease Requiring Chronic Dialysis trials