CompletedNot Applicable

Effects of Repetitive Transcranial Magnetic Stimulation Therapy on Lower Extremity Motor Development in Stroke Patients

Turkey (Türkiye)60 participantsStarted 2022-09-20

Plain-language summary

The aim of our study is to investigate the effects of rTMS applications at different current frequencies (low frequency / intermittent (intermittent) theta burst (iTBS)) in stroke patients on lower extremity motor development, physical function and quality of life, and to compare the effectiveness of these modalities.

Who can participate

Age range

50 Years – 80 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Having lower extremity Brunnstrom motor stage in the 3-5 range, * Having had a stroke at least six months ago, * Being able to walk 5 meters independently with or without an assistive device, * Ability to follow two-stage verbal commands, * To agree to participate in the study voluntarily and regularly, * Being medically stable (without a history of myocardial infarction, without musculoskeletal problems) * Patients with a mini mental test of 24 and above will be accepted into our study. Exclusion Criteria: * Severe heart disease (aortic stenosis, angina, hypertrophic cardiomyopathy, arrhythmia, pacemaker) and a significant comorbid disease such as uncontrolled hypertension, * Cognitive dysfunction, * Visual impairment, * Hearing problem, * Malignancy and active infection, * Skin infection in the rTMS application area, * Open wound, * Inflammatory disease, * Epilepsy, * Brain lesion or a history of drug use that will affect the seizure threshold, * Patients with increased intracranial pressure or uncontrolled migraine will not be included.

Questions worth asking your doctor

Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.

1This trial used repetitive TMS specifically on lower extremity motor problems after stroke — is my type of stroke and the degree of my leg weakness similar enough to the patients in this study that the results might be relevant to my situation?
2The trial measured functional independence using the FIM score at 10 days and 6 weeks after treatment — based on where I am in my recovery, is that timeline realistic for me to see meaningful changes, and how would we track my progress in the same way?
3Since this trial has no assigned phase, meaning it wasn't evaluating a brand-new experimental drug but rather a non-invasive brain stimulation technique, how well-established is repetitive TMS for lower limb recovery specifically, and what does the safety record look like for someone in my condition?
4The study is now completed — have the results been published yet, and if so, did the TMS group actually show meaningful improvements in functional independence compared to a control group, or were the findings inconclusive?
5Would adding repetitive TMS to my current rehabilitation plan be worth discussing with my care team, or is there a standard physiotherapy approach I should try first before considering a technique like this?

Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.

Questions for the trial coordinator

The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.

1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?

A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.

What they're measuring

Change from baseline Functional Independence Measure (FIM) at 10th day and 6th week

Timeframe: up to 6th week

Trial details

NCT IDNCT05554861

SponsorAfyonkarahisar Health Sciences University

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2023-09-20

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